Abstract: Since 2010, the Wixarika (Huichol) indigenous people of western Mexico have struggled against transnational mining activity in their sacred pilgrimage site of Wirikuta in the semi-desertic plateaus of San Luis Potosi. This struggle has been accompanied by a multitude of non-indigenous and largely urban actors who have joined the Wixarika, bringing with them their own cultural, political and geographic registers for understanding and mobilizing against mining in the region.